Exposomics

Program Leadership

Lida Chatzi, MD, PhD

chatzi@usc.edu

John P Wilson, PhD

jpwilson@usc.edu

Exposomics has advanced the use of the exposome framework, encompassing built environments (e.g., walkability, green spaces), natural features (e.g., tree canopy), and chemical/social environments (e.g., PFAS) to understand how exposure mixtures interact with biological and genetic factors to impact health.

Recent Highlights

• Developed a geoexposomic framework integrating geospatial technologies to map personal, residential, and neighborhood exposures.

• Established the U24 NEXUS Network for Exposomics (U24ES036819), designed to advance the science of exposomics by improving measurement and modeling technologies and applying them to human health outcomes.

• Advanced methodologies in mobility data analysis, wildfire smoke exposure prediction using deep learning, and wearable personal monitoring technologies.

• Pioneered studies on the internal exposome, leading to NIH-funded projects like the Multi-Omics for Health and Disease Consortium (U01HG013288)